Human IGF-1

IGF-1, is a hormone similar molecularly to insulin and is produced primarily in the liver. The production of IGF-1 is stimulated by the Growth Hormone (GH). IGF-1 is a central mediator of physiological growth, having growth promoting abilities in almost all cells, especially skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic and lung cells. Recombinant human IGF-1 consist of 70 amino acids, 7.7 kDa. Core IGF-1 is qualified for different applications including the cure of the Laron syndrome (autosomal recessive disorder characterized by the lack of IGF-1), diabetes, osteoporosis, neuromuscular disease and cancer.

Details

Accession Number: P05019
Quantity:

100ug, 500ug, 1000ug. Core Biogenesis is unlocking the powers of the bioeconomy by ensuring the scalability of world changing technologies as regenerative medicine and cellular agriculture. Contact us directly for lot reservation and (large/bulk/industry/production) quantities.

Origin:

IGF-1 is produced in plant seeds of Camelina sativa bred in our laboratories in Strasbourg, France.

Species:

Human. Similarity: -Bovine 90% -Porcine 90% -Mouse 80%

Purity:

≥ 95% measured by SDS page, and resolved under reduced (R) and non-reduced (NR) conditions.

Bioactivity:

The biological activity of human recombinant IGF-1 protein was determined by its ability to promote the proliferation of FDC-P1 cells cultured in adherent condition. Cell proliferation was measured using non-radioactive colorimetric assay and monitored by absorbance. ED50 < 0.1 ng/ml.

Endotoxin Level:

Low endotoxin level ≤ 0.005ng/µg (≤ 0.005EU/ug of protein) as determined by Limulus Amebocyte Lysate assay.

Animal Component-Free:

Xeno-Free Product. Core Biogenesis strictly guarantees that our recombinant proteins have no trace of animal components.

Formulation:

Tris pH 7.4. Our products are shipped in lyophilised format to ensure protein stability in worldwide deliveries.

Preparation:

It is recommended to reconstitute the protein in sterile water to at least a concentration between 0.05-1.0 mg/ml. For dilutions, aliquoting and addition of carrier protein please refer to product’s data sheet or get in touch with our technical support team.

Storage:

Lyophilised protein is stable at room temperature upon arrival. Once it is reconstituted can be stored at -20ºC or -80ºC for up to 1 year.

Featured Application Areas:

Human IGF-1 can be used in a wide variety of areas for cell and molecular biology. We provide high purity and bioactive protein with outstanding performance in: – Cell culture of muscle, bone and cartilage tissue. – Expansion of Mesenchymal Stem Cells (MSCs). -Regulation and proliferation of neural stem cells (NSCs). – Maintenance and differentiation of hematopoietic stem cells (HSCs).

Publications:

Coming soon! Get in touch if you want to become part of our customer spotlight and get special support for your next paper.

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